Immunomodulators (DMARDs) are used in the treatment of conditions that include the following:
FDA-approved:
- Rheumatoid arthritis, an autoimmune inflammatory disease that affects joints
- Psoriatic arthritis, a form of arthritis that develops in people with psoriasis, a skin condition
- Juvenile idiopathic arthritis, a form of arthritis that develops in children
- Juvenile idiopathic arthritis/vasculitis
- Systemic juvenile idiopathic arthritis
- Polyarticular juvenile idiopathic arthritis
- Cryopyrin-associated periodic syndromes (CAPS), a group of rare inherited diseases due to defect in the gene that codes for the protein cryopyrin, which includes:
- Neonatal-onset multisystem inflammatory disease (NOMID) also known as a chronic infantile neurological, cutaneous and articular syndrome (CINCA)
- Deficiency of interleukin-1 receptor antagonist, a rare genetic condition that causes systemic inflammation
- Giant cell arteritis (inflammation of arteries)
- Kidney transplantation, to prevent transplant rejection
- Solid-organ transplant including liver, heart, and kidney, to prevent transplant rejection
- Nephrotic syndrome, a kidney disorder that causes excessive excretion of protein in the urine
- Systemic lupus erythematosus, an autoimmune disease
- Psoriasis
- Malignant diseases (cancers)
- Non-Hodgkin’s lymphoma
- Breast cancer
- Acute lymphoblastic leukemia
- Meningeal leukemia
- Osteosarcoma
- Squamous cell carcinoma of head and neck
- Gestational trophoblastic neoplasia, a rare form of tumor that develops during pregnancy
- Interstitial lung disease, a group of diseases that scar lungs
- Cytokine release syndrome, a systemic inflammatory response triggered by infections or certain drugs
- Ulcerative colitis
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